Magnetic Nanoparticle Hyperthermia for the Treatment of Cancer

Abstract

Treatment of cancer remains a major challenge in modern medicine. Magnetic Hyperthermia is a non-invasive cancer therapy that uses heat generated by magnetic nanoparticles to kill or damage the cancer cells without effecting the healthy cells. Specific absorption rate (SAR) is one of the most important parameters used in designing nanoparticles for the magnetic hyperthermia. In this work we have review physics of magnetic hyperthermia with a focus on effects of nanoparticle size, shape and their aggregation; amplitude and frequency of applied alternating magnetic field on SAR. Some work on synthesis of water based oleic acid coated Fe3O4 nanoparticles have also been reported as it is one of the most important magnetic nanoparticle system which is approved for in-vivo use by food and drug administration of USA.