Association of Aryl Hydrocarbon Receptor gene polymorphism with the risk of Lung Cancer in North Indian population

Abstract

Identification of host differences in the susceptibility to carcinogenesis, especially to cigarette smoking is essential in predicting if one is at a higher risk of acquiring the disease. AhR, an orphan receptor, is a key regulator for the transcription of metabolizers like CYP and the one playing as a housekeeper by maintaining homeostasis, is one of the most widely researched receptor.

The present study was focused to assess the vulnerability of an individual towards Lung cancer having a polymorphism in the exon 10 (rs2066853) and two polymorphism in the intronic region (rs10252882) and (rs 2282885) of AhR, which is a well documented and researched gene. A case control study was performed on the North Indian population. Odds ratio and Class intervals were used to assess the potency of the association. p values were also calculated to find out the statistical significance of the analysis.