An Enantioselective Approach Towards the Synthesis of 3-Aryl Substituted Piperidines: Application to (-)-Preclamol Synthesis
| dc.contributor.author | Sharma, Pooja | |
| dc.contributor.supervisor | Prakash, Ranjana | |
| dc.contributor.supervisor | Pandey, Satyendra Kumar | |
| dc.date.accessioned | 2017-08-08T11:14:44Z | |
| dc.date.available | 2017-08-08T11:14:44Z | |
| dc.date.issued | 2017-08-08 | |
| dc.description | Master of Science -Chemistry | en_US |
| dc.description.abstract | Due to the biological activity of 3-Aryl substituted piperidines and their derivatives in organic chemistry and also their activity in the treatment of Perkinson’s, schizophreni and many other diseases.An enantioselective approach towards the development of a new synthetic route of (-)-preclamol has been attempted employing Henry reaction, asymmetric Michael addition showing the catalytic activity of TMS prolinol, DIBAL-H reduction . The merits of this approach is to provide a high yielding reaction steps. Column chromatography, NMR Spectroscopy were employed to purify and identification of these synthetic intermediates. | en_US |
| dc.identifier.uri | http://hdl.handle.net/10266/4600 | |
| dc.language.iso | en | en_US |
| dc.subject | Aryl Piperidine | en_US |
| dc.subject | Asymmetric Michael addition | en_US |
| dc.subject | Antipsychotic drug | en_US |
| dc.subject | dopamine autoreceptor | en_US |
| dc.subject | 3-PPP | en_US |
| dc.title | An Enantioselective Approach Towards the Synthesis of 3-Aryl Substituted Piperidines: Application to (-)-Preclamol Synthesis | en_US |
| dc.type | Thesis | en_US |