An Enantioselective Approach Towards the Synthesis of 3-Aryl Substituted Piperidines: Application to (-)-Preclamol Synthesis

Abstract

Due to the biological activity of 3-Aryl substituted piperidines and their derivatives in organic chemistry and also their activity in the treatment of Perkinson’s, schizophreni and many other diseases.An enantioselective approach towards the development of a new synthetic route of (-)-preclamol has been attempted employing Henry reaction, asymmetric Michael addition showing the catalytic activity of TMS prolinol, DIBAL-H reduction . The merits of this approach is to provide a high yielding reaction steps. Column chromatography, NMR Spectroscopy were employed to purify and identification of these synthetic intermediates.