Stimuli Responsive Hydrogen Bonded Capsule Formation through Dynamic Self‐Assembly for Guest/Drug Transport

Abstract

Discrete confined cavity pore of molecular capsule is of paramount significance for numerous purposes. If capsule assembled through weak non‐covalent interaction(s) like hydrogen bonding then system can be made responsive for reversible binding/encapsulation of guest molecule. However, more often cavity tends to collapse, especially if such cavity/pore is created by π‒extended purely organic moieties. The situation becomes even more complicated in the solution‐state especially with flexible bridging of receptors, if it can undergo various possible conformation because π•••π interactions typically dominate in the self‐assembly process and surrounding environment also plays a critical role in the molecular assembly. We attempt to short out this problem by implementing self‐sorting and bio‐inspired mutual induce‐fit process (rarely observed in an artificial system). Self‐sorting provides ample opportunity to design and simplify the synthetic scheme through multi‐component assembly. On the other hand mutual induce‐fit provides insight to make control of such dynamic system. The key feature of selfsorted assembly is high fidelity and feasibility to achieve the target in excellent yield that overcome traditional synthetic methodology.