Association of Micro RNA Gene 196a2 and 146a Polymorhism towards Risk for Breast Cancer

Abstract

Micro RNAs are evolutionarily conserved small non-coding RNAs known to inhibit the translation of proteins by binding to the target transcript in the 3' untranslated region. Functional polymorphisms in 3' UTRs of several genes have been reported to be associated with diseases by affecting gene expression. Altered mature Micro RNA processing, mutations, misexpression of micro RNA leads to tumor progression and carcinogenesis. Polymorphism in the micro RNA could alter the overall expression, processing and binding to the target mRNA. Our present study was aimed to investigate the association between two highly studied miRNA genes polymorphisms (mir-146a rs2910164, mir-196a2 rs11614913) towards the risk of breast cancer.A multivariate analysis of various case- control study has been done to find out Odds ratio (OR)and 95% confidence interval (95% CI) which were used to investigate the strength of the association.

- Participants who possessed G/C genotypes for miRNA 146a gene showed have higher risk of breast cancer having OR 1.54(0.78-3.04) when compaired with the miRNA 196a2 genotype C/T having OR 1.30(0.65-2.6).

- The present study suggests an important role of mir-196a2 rs11614913 and rs291014 polymorphism with overall breast cancer risk. Further studies are needed to evaluate so as to confirm their association.