Anti-Inflammatory Responses of Bioavailable Selenium from Selenium-Rich Cereal Grains

Abstract

The Se levels in soil and grains were significantly higher (p<0.001) with their respective non-Se controls. Se-uptake capacity among different cereal crops (wheat, maize and rice) grown on similar seleniferous fields were significantly different from each other (p<0.001). Se levels influence the whole elemental profile with elevated mineral composition in comparison to the non-seleniferous crops.Se levels among four protein fractions, the glutelin and prolamin fractions were dominated over other grains tested. The bioavailability of Se in different protein fractions is directly proportional to its concentration in the fractions. Se as an antioxidant is directly proportional to GPx-1 and H-PGDS expression and have inverse relationship with COX-2, mPGES-1 and iNOS profiles. Among dietary Se supplementation through seleniferous wheat and maize extracts, maize extracts confirm better accessibility of Se, although wheat grains accumulate higher Se levels than maize grains. The role of rMETase in facilitation of free Se from cereal matrices to suppress inflammation has showed significant difference in comparison to SeW and SeM supplementation alone.