Genome-wide analysis of 3D-Domain swapped predicted protein in "Sesamum indicum"

Abstract

3D-Domain swapping is a naturally occurring phenomenon found in every organism, including plants. It is a process of protein oligomerization usually seen in dimers or higher oligomers hinge region, which is also considered the most flexible part of the protein and acquires functional importance. When these structural domains gets switched, the appearance of a "Domain swapped Interface" indicates that the structure is engaged in the domain swapping. The comparison of the hinge fluctuations through molecular dynamics simulation was performed using the GROMACS 2020.1 software. Analysis plots against Root Mean Square Deviation (RMSD), the Radius of Gyration, Root Mean Square Fluctuation (RMSF), and Solvent Accessible Surface Analysis (SASA) were carried out.