Sonication Assisted Aza-Michael Addition to Acrylonitrile under Neat and Catalyst Free Conditions

Abstract

A Highly efficient method for conjugate addition of different amines on α, β –unsaturated compound (acrylonitrile) was developed in search of new greener method for Michael addition reaction. A novel method involving solvent free and catalyst free condition for Michael addition reaction has been achieved under sonication. Michael acceptor and different amines were allowed to react under sonication to obtain various Michael adducts in excellent yields which has not been reported till now. This method can be described as the greenest method for Aza-Michael addition in which reaction involves a simple addition of different molecules (Michael acceptor and a nucleophile). There being not a single by-product of the reaction. Moreover, solvent is not used thereby making the reaction economical and safer.