Towards Alkylation of Aromatic Phenol Assisted by 2,4-Dinitrophenyl Substituent

Abstract

Alkylation on aromatic ring is an important reaction both from industry and synthesis point of view. Evert since the discovery of Friedel-Crafts Alkylation reactions a number of reactions have been reported for in literature. Despite such an important reaction most of the reported procedures use transition metal based reagents. However from environmental point of view metal based reagents need to replaced with organic reagents. The work presented in this thesis describes the concept and attempt to carry out alkylation of phenol, namely resorcinol, using 2,4- dinitrophenol as a substituent. Two alkylating agents ethyl bromide and benzyl bromide gave spots different from starting materials in TLC. However, purification of the alkylated product could not be achieved due to multiple product formation.