An Enantioselective Approach Towards the Total Synthesis of (-)-Heliotridane

Abstract

Pyrrolizidine alkaloids has gained great importance due to their biological activities. They show anticancer, anti HIV- activity, immunostimulatory agent etc. Pyrrolizidine alkaloids has gained great importance in recent years due to their significant biological activities like glycosidases inhibitors1,2 and many other therapeutic uses. (-)-Heliotridane also show similar biological activities like antimitotic, cytotoxic etc. Heliotridane 10 has been isolated as the degradation product of variety of alkaloids found in Heliotrofiiuna, Erechtites, Senecio, Crotalaria and Trichodesma genera so we aim to synthesize (-)-heliotridane by using Henry reaction, Dehydration, L-Proline catalysed asymmetric aldol reaction as the key steps. It was concise, systematic and synthetic approach and was the high yielding method.