Synthesis of Magnetic Nano Drug Delivery Carrier for Cancer Chemotherapy

Abstract

The study related to the biomedical use of iron oxide nanoparticles is of great interest. This is because of the superparamagnetic magnetic nature of the iron oxide nanoparticles that leads to the number of applications of these nanoparticles from separation of cell, hyperthermia to drug delivery. The thesis is focused at synthesis of magnetic drug delivery system that depends on active targeting concept. The core of the drug delivery system is superparamagnetic iron oxide, synthesized by chemical co-precipitation method. Since the surface to volume ratio of nanoparticles is high, it leads to the agglomeration of the nanoparticles to reduce its surface energy. In order to avoid agglomeration of nanoparticles polymer coating of poly ethylene glycol (PEG) is done. To enhance the targeting of magnetic drug system at cancerous sites the PEG coated iron oxide nanoparticles where further modified by Folic acid coating. This helps in promoting active targeting as folate receptors are over expressed on cancerous cells and slightly expressed healthy cells. Doxorubicin is loaded into the magnetic drug delivery system as model chemotherapeutic drug. The designed drug delivery system as well as their components was characterized by vibrating sample magnetometer (VSM), fourier transform infrared spectroscopy (FTIR) and UV-visible spectroscopy. The magnetic nature of the drug delivery system is characterized by VSM, the surface modifications are characterized by FTIR and the drug loading is analyzed by UV-visible spectroscopy. The designed drug delivery system could be targeted to the desired sight by external magnetic field. It is also possible to load multiple anticancer drug into the same drug delivery system to enhance its efficiency.