Genetic Polymorphism in NQO1 gene and its Association with Lung Cancer in North Indian Population

Abstract

Identification of host differences in the susceptibility to carcinogenesis, especially to cigratte smoking is essential in predicting if one is at a higher risk of acquiring the disease. NAD(P)H:quinone oxidoreductase (NQO1) is a detoxification enzyme that protects against the regeneration of reactive oxygen species chemically induced by oxidative stress, cytotoxicity, mutagenicity, and carcinogenicity. The protection conferred by NQO1 protein reduces certain environmental carcinogens, such as nitroaromatic compounds, heterocyclic amines, and possible cigarette smoke condensate. The present study was focused to assess the vulnerability of an individual towards lung cancer having a polymorphism in the rs 1800566 of Nqo1, which is a well documented and researched gene. A case control study was performed on the North Indian population. Odds ratio and class intervals were used to assess the potency of the association. P values were also calculated to find out the statistical significance of the analysis. Cumulative cigarette smoking was interrogated to be a lead player along with other parametrs responsible for susceptibility towards lung Cancer. The combinatorial effect of genotype and histological forms with combined effect of polymorphism was also studied and significant associations were found to exist. The present study provided us with wider platform to study the rs 1800566 polymorphism which are not well studied yet.