Synthesis of Naphthalimide and Imidazo[1,2-a]pyridine Derivatives as Anticancer Agents

Abstract

Cancer is a group of related disease in which some body cells grow uncontrollably. Various anticancer agents have been known for naphthalimide, imidazo[1,2-a]pyridine moieties. Derivatives of naphthalimide with benzothioazole and indole moieties and phosphate and aromatic substituted nitro imidazopyridines have been synthesized. Two naphthalimide derivatives 2-(3-(3-(benzo[d]thiazol-2-yl)-1H-indol-2-yl)phenyl)-6-morpholino-1H-benzo[de]isoquinoline-1,3 (2H)-dione (6b), 2-(3-(3-(benzo[d]thiazol-2-yl)-1H-indol-2-yl)phenyl)-6-(4-methylpiperazin-1-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione (6b) were synthesized and two imidazo[1,2-a]pyridine derivatives tetraethyl(2-(chloromethyl)-3-nitroimi dazo[1,2-a]pyridine-6,8-diyl)bis(phosphonate) (6) and 2-(chloromethyl)-6,8-bis(4-ethylphenyl)-3-nitroimidazo[1,2-a]pyridine (7) were also synthesized and further will be used for its biological activity as anti-cancer agent as well as DNA interactions.