Synthesis and Characterization of 1,3,5-Triazine and Naphthalimide Conjugates as Anticancer Agents

Abstract

Cancer, one of the most threatening diseases in the world that implicates unchecked cell growth and cell division of abnormal cells. When a cell is individually damaged and cannot repair itself, it frequently endures a so called programme that is cell death or apoptosis. The molecules bearing heteroatoms, for instance nitrogen, oxygen and sulfur helps to strengthen the framework through hydrogen bonding with DNA. The anticancer activity is usually related to the force of interaction between DNA and molecule The heterocyclic acquaintance tri-substituted-1,3,5-triazine withstand an intense pharmacophore because of its existence in bulk of bioactive molecules. Derivatives of 1,3,5-triazine bears excellent bioactivity viz. antimicrobial, antitumour, antiprotozal, leishmanicidal, antimalarial and antiviral. In this work, we have synthesized 1,3,5-triazine and naphthalimide base conjugates followed by substitution with primary and secondary amines in good to moderate yields. The synthesized compounds were characterized by 1H NMR spectroscopic technique. These compounds will further be used to evaluate their anticancer activity.