Enantioselective Synthesis of Ephenamine Employing Sharpless Asymmetric Dihydroxylation

Abstract

A pratical and highly enantioselective synthesis of Ephenamine 1 has been achieved by applying Sharpless asymmetric dihydroxylation and cyclic sulfite methodology as the key step. The merits of this synthetic approach is high enantioselective with high yielding steps. This synthetic strategy has significant potential for further extension to other seteroisomers via double inversion at the α-carbon. Pencillin salt of Ephenamine is recommended as an anti-allergenic and used as feed additive to stimulate growth in poultry and livestock and also used to resolve penicillin and glycine derivatives.