Estimation of the Deprotection of Phenols Using 2,4- Dinitro-1-Fluorobenzene using 1H NMR

Abstract

Phenol is one of very reactive groups in organic chemistry due to its high acidity. There are many methodologies available for the protection and deprotection of phenols. This work shows estimation of deprotection of phenols using 1H NMR. The protection of four different phenols has been done using Sanger’s reagent and their deprotection under very mild conditions using aliphatic amine. It is worth mentioning that two nitro groups of Sanger,s reagent are absolutilely necessary for the deprotection of phenols.