An Efficient Approach Towards Total Synthesis of Retinoid Compounds

Abstract

Due to the biological importance of retinoids in neural processes, embryonic development, cell differentiation, proliferation activities, uses as chemotherapeutic drugs and dermatological diseases; we worked on a concise and highly efficient synthetic approach for the synthesis of (E)-5-(2-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl)thiophene-2-carboxylic acid. A series of coupling reaction conditions were explored for the Heck Coupling reaction to form required acid and its methyl ester derivative. Column Chromatography, 1H-NMR, 13C-NMR and FTIR techniques were employed to purify and confirm the formation of compounds using different reaction paths.