Synthesis of amide conjugated oleic acid analogues

Abstract

A series of amide derivatives of oleic acid epoxide were synthesized in this present work. An effective developed method was used for the conjugation of intermediate oleic acid epoxide (2) coupled with different aliphatic, heteroaromatic and heterocyclic amines in dichloromethane (DCM), dimethylaminopyridine (DMAP) and EDCI and synthesized compounds 3-8. All the compounds were purified by column chromatography, identified by TLC and characterized by 1H and 13C NMR. As FAs can cross the blood brain barrier (BBB) and active against various neurological disorders, all synthesized amide conjugated oleic acid analogues will be evaluated for Alzheimer’s/ Parkinson’s diseases on the basis of preliminary screening results.