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|Title:||Synthesis and Characterization of Indole and benzimidazole Conjugates as Anticancer Agents|
|Abstract:||Cancer is a life-threatening disease that can invade anywhere in the body tissues. Abnormal growth/division of cells cause cancer. When a cell is individually damaged and cannot repair itself, it frequently endures a so called programme that is cell death or apoptosis. Optimisation of drugs is done at the molecular level in order to produce an improved version of anticancer drug. Indole exhibits immense biological activity and has always attracted researchers to design target-based compounds possessing indole moiety as anticancer agents and become one of the important building blocks of many drug development and research centers. In this work, we have synthesized indole and benzimidazole based conjugates followed by Suzuki coupling with various boronic acids in good to moderate yields. The synthesized compounds were characterized by 1H NMR spectroscopic technique. These compounds will further be used to evaluate their anticancer activity.|
|Appears in Collections:||Masters Theses@SCBC|
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