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Title: Macromolecular Crowding-Induced Molten Globule State of Acid-Denatured Horse Cytochrome c
Authors: Goyal, Neha
Supervisor: Kumar, Rajesh
Keywords: Molten Globule State;Cytochrome c
Issue Date: 4-Sep-2014
Abstract: This work examined the effect of concentration and size of crowding agents (dextran 40 and dextran 70) on structure, stability and folding of acid-denatured ferricytochrome c at pH 2.0. As [dextran] is increased in the UA state , the intensity of flouroscence emission spectra decreases, which indicates molecular compaction of UA state. The crowding agents stabilize and refold the acid-denatured ferricytochrome c (pH 2.0) to MG-states. The acid-denatured ferricytochrome c also gains substantial secondary structure content but not acquire tertiary structure content in the presence of high concentrations of crowding agent.
Description: MS, SCBC
Appears in Collections:Masters Theses@SCBC

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