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Title: L-Proline Catalyzed Asymmetric Synthesis of Serotonin Norepinephrine Reuptake Inhibitors
Authors: Avneet, Kaur
Supervisor: Pandey, Sateyendra Kumar
Keywords: Oxidation;L-proline catalysed Aldol reaction;protection of amine group
Issue Date: 2-Sep-2014
Abstract: An enantio- and diastereo selective synthesis of SNRIs (Serotonin Norepinephrine Reuptake inhibitors) compound 7 and 8 has been attempted employing protection of amine group, Swern oxidation and L- Proline catalyzed asymmetric cross aldol reaction as the key steps. These SNRIs compounds are potent inhibitors of serotonin (5-HT) and norepinephrine (NE) reuptake. Beside being used widely as an antidepressants, these can also be used to treat various disorders, such as depression, neuropathic pain,anxiety disorders, obsessive-compulsive disorder (OCD), and attention deficit hyperactivity disorder (ADHD). They show balanced activity at both the transporters and minimizes the drug-drug interactions.The merit of this synthesis is high yielding reaction steps as asymmetric catalyst.
Description: M Sc Thesis
Appears in Collections:Masters Theses@SCBC

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