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http://hdl.handle.net/10266/3118
Title: | L-Proline Catalyzed Asymmetric Synthesis of Serotonin Norepinephrine Reuptake Inhibitors |
Authors: | Avneet, Kaur |
Supervisor: | Pandey, Sateyendra Kumar |
Keywords: | Oxidation;L-proline catalysed Aldol reaction;protection of amine group |
Issue Date: | 2-Sep-2014 |
Abstract: | An enantio- and diastereo selective synthesis of SNRIs (Serotonin Norepinephrine Reuptake inhibitors) compound 7 and 8 has been attempted employing protection of amine group, Swern oxidation and L- Proline catalyzed asymmetric cross aldol reaction as the key steps. These SNRIs compounds are potent inhibitors of serotonin (5-HT) and norepinephrine (NE) reuptake. Beside being used widely as an antidepressants, these can also be used to treat various disorders, such as depression, neuropathic pain,anxiety disorders, obsessive-compulsive disorder (OCD), and attention deficit hyperactivity disorder (ADHD). They show balanced activity at both the transporters and minimizes the drug-drug interactions.The merit of this synthesis is high yielding reaction steps as asymmetric catalyst. |
Description: | M Sc Thesis |
URI: | http://hdl.handle.net/10266/3118 |
Appears in Collections: | Masters Theses@SCBC |
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