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Title: Approach towards synthesis of 2-Alkyl substituted tetrahydroquinolines
Authors: Sharma, Poonam
Supervisor: Pandey, Satyendra Kumar
Keywords: Tetrahydroquinolines synthesis;Jacobsens catalysts
Issue Date: 5-Sep-2013
Abstract: A practical and enantioselective synthesis of (S)-Angustureine has been targeted from (R)-Epichlorohydrin 5a employing jacobsen's HKR, Grignard reaction as the key steps. We have successfully completed the trial reaction for intermediate 6. The work is under progress in further direction to achieve the target compounds. The merits of this synthetic approach is high yielding reaction steps. This synthetic strategy has significant potential for further extension to synthesis of galipeine 2, cuspareine 3 and galipinine 4
Description: Master of Science-Chemistry, Dissertation
Appears in Collections:Masters Theses@SCBC

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